Population
Humans, including patients with untreated essential hypertension
Design
Other
Authors
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Endothelin-targeted therapies merit exploration in hypertension; hypothesis-generating and requires prospective trials before practice change.
Endogenous endothelin-1 plays a fundamental physiological role in maintaining basal vascular tone, highlighting endothelin receptor antagonists and converting enzyme inhibitors as potential therapeutic targets.
William G. Haynes (1995) studied this question.
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