February 1, 1991Journal of Applied Physiology

Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation

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Population

Intact spontaneously breathing cats under conditions of constant pulmonary blood flow and left atrial pressure

Comparison

Intralobar bolus injections of ET-1, ET-2, and… vs Responses in the presence of blocking agents

Design

Preclinical

Authors

HLHoward LipptonTulane University GCGordon CohenUniversity of Arizona IMIvan F. McMurtryAmerican Heart Association

Discussion

Member takes

Implication

May support K-channel mediation of ET-induced pulmonary vasodilation in animals; leaves open translation to human pulmonary hypertension.

Structured PICO

Population

Intact spontaneously breathing cats under conditions of constant pulmonary blood flow and left atrial pressure

Intervention

Intralobar bolus injections of ET-1 (1 microgram), ET-2 (1 microgram), and ET-3 (3 micrograms) during actively increased pulmonary vasomotor tone (via U-46619 infusion)

Comparator

Responses in the presence of blocking agents (atropine, indomethacin, ICI 118551, and glybenclamide)

Outcome

Changes in pulmonary and systemic vascular resistances and pressuressurrogate

Endothelin isopeptides (ET-1, ET-2, ET-3) dilate the pulmonary vascular bed in vivo, a response that depends on preexisting vasomotor tone and is partly mediated by potassium channel activation.

Cite This Study

Lippton et al. (1991) studied this question.

synapsesocial.com/papers/6a87368237e82e140d1548d9 https://doi.org/10.1152/jappl.1991.70.2.947

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Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider