June 1, 1997British Journal of PharmacologyOpen Access

Pharmacological characterization of endothelin‐induced rat pulmonary arterial dilatation

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Population

Isolated extrapulmonary rat arteries and intrapulmonary arteries preconstricted with 1 microM phenylephrine

Design

Preclinical

Authors

THTooru HigashiUniversity of Fukui TITakeshi IshizakiUniversity of Fukui KSK. ShigemoriUniversity of Fukui

Discussion

Member takes

Implication

Regional ETB-mediated vasodilatation varies in rat pulmonary arteries; hypothesis-generating but should not yet inform human pulmonary hypertension management.

Structured PICO

Population

Isolated extrapulmonary rat arteries (EPA) and intrapulmonary arteries (IPA) preconstricted with 1 microM phenylephrine

Intervention

Endothelin-1 (ET-1) and Endothelin-3 (ET-3) (1 nM-100 nM), with or without antagonists (BQ788, BQ123, glibenclamide, L-NMMA) or endothelium denudation

Outcome

Vasodilatationsurrogate

Endothelin-induced vasodilatation in rat pulmonary arteries is mediated by endothelial ETB receptors, involves ATP-sensitive K+ channels and nitric oxide synthase, and varies by arterial region.

Cite This Study

Higashi et al. (1997) studied this question.

synapsesocial.com/papers/6a8be9ae7239707559bed994 https://doi.org/10.1038/sj.bjp.0701177

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Implication

Regional ETB-mediated vasodilatation varies in rat pulmonary arteries; hypothesis-generating but should not yet inform human pulmonary hypertension management.

Pharmacological characterization of endothelin‐induced rat pulmonary arterial dilatation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacological characterization of endothelin‐induced rat pulmonary arterial dilatation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider