Key result
ET-1-induced constrictions are mediated by both ET(A) and ET(B) receptors in intrapulmonary arteries and by ET(A) in extrapulmonary arteries, suggesting pharmacological heterogeneity of ET(A).
Population
Isolated intrapulmonary artery (IPA) and extrapulmonary artery (EPA) from rats
Design
Preclinical
Authors
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Rat pulmonary artery data should not alter ET antagonist use in patients; hypothesis-generating for regional receptor heterogeneity in human disease.
This preclinical study demonstrates pharmacological heterogeneity in endothelin receptor-mediated vasoconstriction across different regions of the rat pulmonary vasculature.
Higashi et al. (1997) studied this question. Endothelin receptor agonists and antagonists was evaluated on Pulmonary arterial constriction. ET-1-induced constrictions are mediated by both ET(A) and ET(B) receptors in intrapulmonary arteries and by ET(A) in extrapulmonary arteries, suggesting pharmacological heterogeneity of ET(A).
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