Population
Isolated small porcine pulmonary arteries and veins
Design
Preclinical
Authors
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No immediate clinical implications from porcine data; leaves open translation to human pulmonary vascular disease.
ET-1 is a potent vasoconstrictor of porcine pulmonary vessels that also stimulates the release of opposing vasodilators (EDNO and prostacyclin), with greater release in pulmonary veins.
Zellers et al. (1994) studied this question.
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