Key result
Blockade of nitric oxide synthase or ET(B) receptors triggers a rise in endothelin-1 or its precursor, inducing pressor effects mediated by ET(A) receptors in anesthetized rabbits.
In anesthetized rabbits, pressor effects induced by nitric oxide synthase or ET(B) receptor blockade are mediated through the activation of ET(A) receptors by increased levels of endothelin-1 or its precursor.
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Extends ET(A) mediation evidence in rabbit models; leaves open human hypertension relevance.
Gratton et al. (1997) studied Blood pressure regulation. BQ-123, BQ-788, L-NAME, phosphoramidon was evaluated on Mean arterial pressure and plasma levels of endothelin-1 and big endothelin-1. Blockade of nitric oxide synthase or ET(B) receptors triggers a rise in endothelin-1 or its precursor, inducing pressor effects mediated by ET(A) receptors in anesthetized rabbits.
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