Why the study?
Does ETA-receptor blockade with BQ-610 alter the systemic and renal vasoconstriction induced by nitric oxide inhibition in anesthetized rats?
Does ETA-receptor blockade with BQ-610 alter the systemic and renal vasoconstriction induced by nitric oxide inhibition in anesthetized rats?
Endothelin receptor A blockade partially reverses systemic and renal vasoconstriction induced by nitric oxide inhibition in rats, suggesting endothelin mediates part of this response.
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ETA blockade may mitigate NO inhibition effects in rats; leaves open any human therapeutic role.
Thompson et al. (1995) studied this question.
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