Why the study?
Does endothelin-A blockade with BQ-123 attenuate the systemic and renal hemodynamic effects of L-NAME in humans?
Does endothelin-A blockade with BQ-123 attenuate the systemic and renal hemodynamic effects of L-NAME in humans?
Endothelin-A blockade attenuates systemic and renal vasoconstriction induced by nitric oxide synthase inhibition, suggesting an interaction between endogenous NO and ET-A activity in maintaining vascular tone.
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No immediate clinical implications for hypertension; leaves open ET-A/NO interactions as therapeutic targets.
Montanari et al. (2000) studied this question.
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