Why the study?
Does alpha1-adrenoceptor and AT1-receptor blockade alter L-NAME-induced systemic and renal vasoconstrictor responses in hypertensive individuals?
Population
13 hypertensive individuals, mean age 47 +/- 9 years, pretreated with hydrochlorothiazide (25 mg once daily).
Comparison
L-NAME administered during alpha1-adrenoceptor… vs Placebo administration.
Design
Other
Follow-up
Acute (40 min clearance periods)
Authors
Loading...
AT1-receptor blockade abolishes L-NAME-potentiated vasoconstriction during alpha1-blockade; leaves open whether this interaction alters long-term outcomes in hypertension.
Does alpha1-adrenoceptor and AT1-receptor blockade alter L-NAME-induced systemic and renal vasoconstrictor responses in hypertensive individuals?
L-NAME-induced systemic and renal vasoconstrictor responses are potentiated during alpha1-adrenoceptor blockade, an effect that is abolished by AT1-receptor antagonism.
Linde et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: