Why the study?
Does nitric oxide synthase inhibition with L-NAME alter renal responses to water and saline loading and blood pressure in conscious dogs?
Population
Conscious dogs undergoing sustained water diuresis and replacement of urinary sodium losses
Comparison
L-NAME (10 microg. kg. min) infusion, with and… vs Control conditions without L-NAME
Design
Preclinical
Authors
Loading...
Highlights nitric oxide's role in renal excretory responses in dogs; leaves open translation to human hypertension or volume disorders.
Does nitric oxide synthase inhibition with L-NAME alter renal responses to water and saline loading and blood pressure in conscious dogs?
Nitric oxide synthase inhibition with L-NAME increases blood pressure and blunts the renal responses to water and saline loading in conscious dogs.
Peterson et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: