Nitric oxide and renal effects of volume expansion in conscious monkeys

Conscious cynomolgus monkeys

Volume expansion with 3% dextran in normal saline during constant infusion of the NO synthase inhibitor L-NAME (30 microg x kg(-1) x min(-1)) with or without simultaneous infusion of L-arginine (0.6 mg x kg(-1) x min(-1))

Control state (volume expansion alone)

Renal responses to volume expansion (urine flow and sodium excretion)surrogate