Key result
Central administration of endothelin-1 significantly increased baroreflex gain in both spontaneously hypertensive and Wistar-Kyoto rats by increasing the curvature coefficient.
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls
Comparison
Intracisternal injection of endothelin-1 or… vs Baseline/untreated state and between-strain…
Design
Preclinical
Authors
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Hypothesis-generating for central endothelin-1 in baroreflex control; no clinical implications and requires human translation.
Central administration of endothelin-1 sensitizes the baroreceptor heart rate reflex similarly in both spontaneously hypertensive and normotensive rats, indicating the mechanism is distinct from the underlying reflex sensitivity differences between these strains.
Buuse et al. (1993) studied Hypertension. Intracisternal injection of endothelin-1 vs. Baseline / WKY controls was evaluated on Baroreceptor heart rate reflex gain. Central administration of endothelin-1 significantly increased baroreflex gain in both spontaneously hypertensive and Wistar-Kyoto rats by increasing the curvature coefficient.
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