January 1, 1999Journal of Hypertension

Functional characterization of endothelin receptors in hypertensive resistance vessels

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Population

12-week-old spontaneously hypertensive rats and Wistar-Kyoto rats

Comparison

Endothelin-1 and sarafotoxin S6c, with or… vs WKY rats and responses without…

Design

Preclinical

Authors

MMMonica MontagnaniUniversity of Bari Aldo Moro MPMaria Assunta PotenzaPolyclinic Medical Center RRRosanna RinaldiCarlo Forlanini Hospital

Discussion

Member takes

Implication

May implicate prostanoids in ET-1 hyperreactivity in hypertensive models; leaves open human translation.

Structured PICO

Population

12-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats (perfused mesenteric vascular bed model)

Intervention

Endothelin-1 (0.2-2 mumol/l) and sarafotoxin S6c, with or without indomethacin, BQ-485 (ETA antagonist), and BQ-788 (ETB antagonist)

Comparator

WKY rats (normotensive controls) and responses without antagonists/indomethacin

Outcome

Vasoconstriction and relaxation responses (concentration-response curves)surrogate

In spontaneously hypertensive rats, increased vasoconstriction to endothelin-1 is mediated by ETA receptors and prostanoid production, alongside a loss of ETB-mediated relaxation.

Cite This Study

Montagnani et al. (1999) studied this question.

synapsesocial.com/papers/6a7064cdf44fa9f079de0825 https://doi.org/10.1097/00004872-199917010-00008

Topics

Hypertension management

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Functional characterization of endothelin receptors in hypertensive resistance vessels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Functional characterization of endothelin receptors in hypertensive resistance vessels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider