Population
20 rats aged 12 weeks; mesenteric small resistance arteries
Comparison
Endothelin-1 cumulative concentrations with and… vs Absence of antagonist/agonist; WKY rats vs SHR
Design
Preclinical
Authors
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ETA receptors mediate ET-1 vasoconstriction in rat resistance arteries; hypothesis-generating for selective antagonists in human hypertension.
The contractile effects of ET-1 on mesenteric small resistance arteries in both SHR and WKY rats are mediated primarily by ETA receptors, with ETB receptors playing little to no role.
Rizzoni et al. (1997) studied this question.
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