April 1, 1995Hypertension
ETAand ETBReceptors Mediate Contraction to Endothelin-1 in Renal Artery of Aging SHR
Key result
Both ETA and ETB receptors mediate contraction to endothelin-1 in the renal artery from spontaneously hypertensive rats but not Wistar-Kyoto rats, with ETB receptors unmasked with age in SHR.
Population
Renal arteries from adult and old spontaneously hypertensive rats and age-matched Wistar-Kyoto rats
Comparison
Endothelin-1, FR139317, bosentan, and… vs Age-matched Wistar-Kyoto rats and adult vs old…
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating in aged SHR renal arteries; leaves open relevance to human hypertensive nephropathy.
Structured PICO
P
Population
Adult and old spontaneously hypertensive rats and age-matched Wistar-Kyoto rats used to characterize vascular endothelin receptors in the renal artery.
I
Intervention
Endothelin-1, FR139317 (ETA receptor antagonist), bosentan (combined ETA/ETB receptor antagonist), and sarafotoxin S6c (ETB-selective agonist)
C
Comparator
Age-matched Wistar-Kyoto rats (WKY) and adult vs old comparisons
O
Outcome
Isometric tension (vascular contraction and relaxation)surrogate
Main Result
p-value: p=<.05
In spontaneously hypertensive rats, aging unmasks ETB receptor-mediated vasoconstriction in the renal artery, whereas in normotensive rats, aging enhances ETB-mediated vasorelaxation.
Cite This Study
Seo et al. (1995) studied Hypertension (animal model). Endothelin receptor antagonists (FR139317, bosentan) and agonists (sarafotoxin S6c) vs. Wistar-Kyoto rats (WKY) and different age groups was evaluated on Vascular contraction and relaxation responses (p=<.05). Both ETA and ETB receptors mediate contraction to endothelin-1 in the renal artery from spontaneously hypertensive rats but not Wistar-Kyoto rats, with ETB receptors unmasked with age in SHR.