February 1, 1995Hypertension
Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta
Key result
Aging causes different alterations in endothelium and smooth muscle in normotensive and hypertensive rat aortas, involving impaired nitric oxide in senescent rats.
Population
12-week-old and 72-week-old normotensive Wistar-Kyoto rats and spontaneously hypertensive rats
Comparison
Ex vivo pharmacological testing on suspended… vs Comparison between adult vs. senescent and…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Caution against extrapolating rat aging effects to human hypertension; leaves open mechanisms and clinical relevance.
Structured PICO
P
Population
Adult (12-week-old) and senescent (72-week-old) normotensive Wistar-Kyoto rats and spontaneously hypertensive rats.
E
Exposure
Ex vivo pharmacological testing (acetylcholine, SQ 30741, sodium nitroprusside, L-NAME, U46619, norepinephrine, endothelin-1, bosentan) on suspended aortas
C
Comparator
Comparison between adult vs. senescent and normotensive (WKY) vs. hypertensive (SHR) rats
O
Outcome
Isometric tension (endothelium-dependent relaxations and contractions)surrogate
Aging and hypertension cause endothelial dysfunction through distinct mechanisms, involving prostaglandin H2 in adult hypertensive rats and nitric oxide impairment in senescent rats.
Cite This Study
Küng et al. (1995) studied Hypertension and aging. Aging and hypertension vs. Adult normotensive rats was evaluated on Endothelium-dependent relaxations and contractions. Aging causes different alterations in endothelium and smooth muscle in normotensive and hypertensive rat aortas, involving impaired nitric oxide in senescent rats.