Why the study?
Does hypertension or aging impair NO-mediated relaxation response to acetylcholine in the rat aorta?
Population
Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats at ages 16-20 and 55-60 weeks
Comparison
Acetylcholine after treatment with… vs Age-matched WKY rats and younger rats
Design
Preclinical
Authors
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Aging attenuates NO-mediated aortic relaxation independently of hypertension in rats; leaves open translation to human vascular aging.
Does hypertension or aging impair NO-mediated relaxation response to acetylcholine in the rat aorta?
In a rat model, NO-mediated aortic relaxation is attenuated by aging but not impaired by hypertension.
Imaoka et al. (1999) studied this question.
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