January 1, 1990Clinical and Experimental Hypertension

In Vitro Vascular Reactivity to Endothelin: A Comparison Between Young and Old Normotensive and Hypertensive Rats

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Why the study?

Does aging affect the vascular smooth muscle responsiveness to endothelin-1 in spontaneously hypertensive rats compared to normotensive rats?

Population

Spontaneously hypertensive rats and age-matched normotensive Wistar-Kyoto rats at 11, 22, 33, and 44 weeks…

Comparison

In vitro exposure to endothelin-1 vs Normotensive WKY rats and different age groups

Design

Preclinical

Authors

GCGabriella CargnelliUniversity of Padua GRGian Paolo RossiGeneral Cardiology SBSergio BovaUniversity of Padua

Discussion

Member takes

Implication

Suggests age-related ET-1 hyporesponsiveness in hypertensive models; leaves open translation to human aging and hypertension.

Structured PICO

Does aging affect the vascular smooth muscle responsiveness to endothelin-1 in spontaneously hypertensive rats compared to normotensive rats?

Population

Spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto (WKY) rats at 11, 22, 33, and 44 weeks of age

Intervention

In vitro exposure to endothelin-1

Comparator

Normotensive WKY rats and different age groups

Outcome

Isometric contractions of spirally cut aortic stripssurrogate

Aging is associated with a progressive decrease in aortic responsiveness to endothelin-1 in spontaneously hypertensive rats, suggesting potential desensitization.

Cite This Study

Cargnelli et al. (1990) studied this question.

synapsesocial.com/papers/6a972ad53b31fa02463c0316 https://doi.org/10.3109/10641969009073529

Topics

Hypertension management

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