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January 1, 1973Acta Physiologica Scandinavica

Role of Cyclic AMP and Ca++in Mechanical and Metabolic Events in Isometrically Contracting Vascular Smooth Muscle

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Population

Bovine mesenteric artery (vascular smooth muscle)

Comparison

Adrenergic alpha- and beta-receptor stimulation… vs Ca++-poor artery conditions and baseline states

Design

Preclinical

Authors

RARolf G. G. AnderssonLinköping University

Discussion

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Implication

Requires caution before clinical extrapolation; extends animal data on vascular cAMP signaling but leaves open human relevance.

Structured PICO

P
Population
Bovine mesenteric artery (vascular smooth muscle)
I
Intervention
Adrenergic alpha- and beta-receptor stimulation (catecholamines), histamine, and specific antagonists (sotalol, dibenamine, promethazine)
C
Comparator
Ca++-poor artery conditions and baseline states
O
Outcome
Changes in cyclic AMP content, phosphorylase a activation, ATP, creatinephosphate (CrP), and phosphodiesterase activitysurrogate

This study elucidates the complex, time-dependent, and calcium-sensitive roles of cyclic AMP in mediating relaxation and contraction of vascular smooth muscle following adrenergic and histaminergic stimulation.

Cite This Study

Rolf G. G. Andersson (1973) studied this question.

synapsesocial.com/papers/6a86dae648ef9afcd2a245aehttps://doi.org/10.1111/j.1748-1716.1973.tb05369.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Action of Epinephrine and Glucagon on the Canine Heart: EVIDENCE FOR INCREASE IN SARCOTUBULAR CALCIUM STORES MEDIATED BY CYCLIC 3',5'-AMP1969 · 198 citations
  2. 2Length at Inactivated Contractile Elements, Length‐tension Diagram Active State and Tone of Vascular Smooth Muscle1966 · 66 citations
  3. 3Relationship between Cyclic AMP, Phosphodiesterase Activity, Calcium and Contraction in Intestinal Smooth Muscle1973 · 33 citations