Population
Bovine aortic native actomyosin
Comparison
Cyclic AMP and its dependent protein kinase vs Cyclic AMP alone or protein kinase alone
Design
Preclinical
Authors
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Hypothesis-generating for cAMP-mediated vascular relaxation; no basis for clinical practice change pending human data.
cAMP-mediated inhibition of myosin light chain phosphorylation may represent a direct mechanism for beta-adrenergic relaxation in mammalian vascular smooth muscle.
Silver et al. (1979) studied this question.
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