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July 1, 1978Experimental Biology and Medicine

Ca2+ Dependent Phosphorylation of Bovine Aortic Actomyosin

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Population

Bovine aortic actomyosin

Design

Preclinical

Authors

JDJ. DiSalvoCornell UniversityEGEric GruensteinUniversity of Cincinnati Medical CenterPSPaul J. SilverTemple University

Discussion

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Implication

Animal data link myosin phosphorylation to vascular actomyosin activation; leaves open human translation and therapeutic relevance.

Structured PICO

P
Population
Bovine aortic actomyosin
I
Intervention
Ca2+ exposure
O
Outcome
Phosphorylation of 15,000 dalton polypeptides (myosin light chains)surrogate

The Ca2+ regulatory mechanism for actin-myosin interactions in mammalian vascular smooth muscle may be partly mediated by phosphorylation of myosin light chains.

Cite This Study

DiSalvo et al. (1978) studied this question.

synapsesocial.com/papers/6a7270543ce530166bc352d4https://doi.org/10.3181/00379727-158-40215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationships between Ca2+, Myosin Light Chains, and ATPase in Bovine Aortic Actomyosin: Presence of Ca2+-Requiring Inactivation Factor1979 · 8 citations
  2. 2Phosphatase-Mediated Modulation of Actin-Myosin Interaction in Bovine Aortic Actomyosin and Skinned Porcine Carotid Artery1985 · 22 citations
  3. 3Ca‐Linked Phosphorylation of a Light Chain of Vertebrate Smooth‐Muscle Myosin1977 · 196 citations
  4. 4Calcium regulation of porcine aortic myosin.1981 · 46 citations
  5. 5Ca-Regulation of Mammalian Smooth Muscle Actomyosin via a Kinase-Phosphatase-Dependent Phosphorylation and Dephosphorylation of the 20000-Mr Light Chain of Myosin1977 · 133 citations