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November 1, 1999AJP Heart and Circulatory Physiology

ACE inhibitors in HF restore canine pulmonary endothelial function and ANG II vasoconstriction

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Why the study?

Does ramipril restore pulmonary endothelial function and ANG II vasoconstriction in dogs with chronic mitral regurgitation?

Population

Dogs with 4 months of chronic mitral regurgitation (MR) and control dogs

Comparison

Ramipril (ACE inhibitor) vs Untreated MR dogs and untreated control dogs

Design

Preclinical

Follow-up

4 months

Authors

ISIngrid M. Straeter‐KnowlenUniversity of Alabama at BirminghamLDLouis J. Dell’ItaliaHeart Failure & TransplantJDJun DaiShanghai Jiao Tong University

Discussion

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Implication

May warrant ACE inhibitor evaluation in MR-related pulmonary hypertension; leaves open translation from canine models to clinical practice.

Structured PICO

Does ramipril restore pulmonary endothelial function and ANG II vasoconstriction in dogs with chronic mitral regurgitation?

P
Population
Dogs with 4 months of chronic mitral regurgitation (MR) and control dogs
I
Intervention
Ramipril (ACE inhibitor)
C
Comparator
Untreated MR dogs and untreated control dogs
O
Outcome
Pulmonary artery (PA) responses to angiotensin (ANG) II and bradykinin (BK)surrogate

ACE inhibitor therapy with ramipril restores impaired pulmonary vasomotion to ANG II and bradykinin in a canine model of chronic mitral regurgitation, supporting their use in chronic congestive heart failure.

Cite This Study

Straeter‐Knowlen et al. (1999) studied this question.

synapsesocial.com/papers/6a98f3cf4f4bbec9e275bc02https://doi.org/10.1152/ajpheart.1999.277.5.h1924
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preservation of Endothelial Function by Ramipril in Rabbits on a Long-Term Atherogenic Diet1991 · 89 citations
  2. 2Release of Endothelium-Derived Relaxing Factors from Canine Cardiac Valves1990 · 34 citations
  3. 3The role of the renin‐angiotensin and natriuretic peptide systems in the pulmonary vasculature.1995 · 36 citations
  4. 4Congestive heart failure alters receptor-dependent cAMP-mediated relaxation of canine pulmonary arteries.1993 · 24 citations
  5. 5Altered Ventricular and Myocyte Response to Angiotensin II in Pacing-Induced Heart Failure1996 · 99 citations