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August 1, 2000AJP Renal Physiology

Roles of ANG II and bradykinin in the renal regional blood flow responses to ACE inhibition in sodium-depleted dogs

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Why the study?

Does enalaprilat increase renal cortical and medullary blood flow via bradykinin potentiation in sodium-depleted dogs after AT1 receptor blockade?

Population

7 dogs fed a low-salt diet (0.01%) for 5 days

Comparison

Intraarterial administration of enalaprilat (33… vs Candesartan alone, and subsequent administration…

Design

Preclinical

Authors

SOSophia A. OmoroTulane UniversityDMDewan S. A. MajidTulane UniversitySDSamir S. El DahrTulane University

Discussion

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Overview

Highlights bradykinin potentiation in ACEI renal vasodilation in dogs; leaves open translation to human cardiorenal therapies.

Structured PICO

Does enalaprilat increase renal cortical and medullary blood flow via bradykinin potentiation in sodium-depleted dogs after AT1 receptor blockade?

P
Population
7 dogs fed a low-salt diet (0.01%) for 5 days
I
Intervention
Intraarterial administration of enalaprilat (33 microg. kg(-1). min (-1)) after blockade of the ANG II AT(1) receptors with candesartan (100 microg)
C
Comparator
Candesartan alone, and subsequent administration of the BK B(2) receptor blocker icatibant (300 microg)
O
Outcome
Renal cortical (CBF) and medullary blood flow (MBF) responses measured by laser-Doppler flowmetrysurrogate

ACE inhibitor-induced renal vasodilation in sodium-depleted dogs is substantially mediated by bradykinin potentiation, with a greater effect on medullary compared to cortical blood flow.

Cite This Study

Omoro et al. (2000) studied this question.

synapsesocial.com/papers/6a87e2f824ca9e5e63016348https://doi.org/10.1152/ajprenal.2000.279.2.f289
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kinin influences on renal regional blood flow responses to angiotensin-converting enzyme inhibition in dogs1999 · 30 citations
  2. 2Bradykinin contribution to renal blood flow effect of angiotensin converting enzyme inhibitor in the conscious sodium-restricted dog.1990 · 63 citations
  3. 3Renin-angiotensin system modulates renal bradykinin production1996 · 112 citations
  4. 4Role of kinins and angiotensin II in the renal hemodynamic response to captopril1991 · 59 citations
  5. 5Renal Interstitial Fluid Angiotensin1995 · 140 citations