What is the clinical evidence from this study?

Study design: Other. Intervention: Angiotensin II infusion vs. baseline and various inhibitors (enalapril, ketoprofen, aprotinin, L-NAME, losartan). Primary outcome: Papillary blood flow (PBF), cortical blood flow (CBF), total renal blood flow (RBF), and mean arterial pressure (MAP).

January 1, 2000Blood PressureOpen Access

Regional Renal Haemodynamics of Angiotensin II Infusion under Prostaglandin, Kinin or Converting Enzyme Inhibition in the Wistar Rat

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Key result

Angiotensin II infusion did not change papillary blood flow, but increased mean arterial pressure by 10% and decreased renal and cortical blood flow in anaesthetised Wistar rats.

Population

Anaesthetised Wistar rats

Design

Preclinical

Authors

JRJonas RudenstamUniversity of Gothenburg

Discussion

Member takes

Implication

Supports papillary autoregulation hypotheses in rats; leaves open any clinical relevance to human hypertension.

Structured PICO

Population

Anaesthetised Wistar rats evaluated for renal haemodynamic responses to Angiotensin II infusion.

Intervention

Angiotensin II (30 ng kg(-1) min(-1)) infusion alone and after ACE inhibition (enalapril), bradykinin/prostaglandin synthesis inhibition (ketoprofen, aprotinin), or NO blockade (L-NAME) with or without losartan

Outcome

Total renal blood flow (RBF), cortical blood flow (CBF), papillary blood flow (PBF), and mean arterial pressure (MAP)surrogate

The increase in papillary blood flow to Ang II after enalapril treatment suggests ACE inhibitors may affect the sensitivity of renal papillary autoregulation, contributing to their blood pressure-lowering effect.

Cite This Study

Jonas Rudenstam (2000) studied this question. Angiotensin II infusion vs. baseline and various inhibitors (enalapril, ketoprofen, aprotinin, L-NAME, losartan) was evaluated on Papillary blood flow (PBF), cortical blood flow (CBF), total renal blood flow (RBF), and mean arterial pressure (MAP). Angiotensin II infusion did not change papillary blood flow, but increased mean arterial pressure by 10% and decreased renal and cortical blood flow in anaesthetised Wistar rats.

synapsesocial.com/papers/6a94df0b1fe04514d10f2e04 https://doi.org/10.1080/080370500453528

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January 1, 2000Blood PressureOpen Access

Regional Renal Haemodynamics of Angiotensin II Infusion under Prostaglandin, Kinin or Converting Enzyme Inhibition in the Wistar Rat

View Full Paper

Ask AI

Bookmark

Key result

Angiotensin II infusion did not change papillary blood flow, but increased mean arterial pressure by 10% and decreased renal and cortical blood flow in anaesthetised Wistar rats.

Population

Anaesthetised Wistar rats

Design

Preclinical

Authors

JRJonas RudenstamUniversity of Gothenburg

Discussion

Member takes

Implication

Supports papillary autoregulation hypotheses in rats; leaves open any clinical relevance to human hypertension.

Structured PICO

Population

Anaesthetised Wistar rats evaluated for renal haemodynamic responses to Angiotensin II infusion.

Intervention

Outcome

Total renal blood flow (RBF), cortical blood flow (CBF), papillary blood flow (PBF), and mean arterial pressure (MAP)surrogate

Cite This Study

synapsesocial.com/papers/6a94df0b1fe04514d10f2e04 https://doi.org/10.1080/080370500453528

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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