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May 1, 1991AJP Renal Physiology

Role of kinins and angiotensin II in the renal hemodynamic response to captopril

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Population

Munich-Wistar rats with elevated plasma renin activity, renal denervation, and controlled renal perfusion…

Comparison

Captopril with subsequent infusions of ANG II… vs Baseline/control state

Design

Preclinical

Authors

DMDavid L. MattsonAugusta UniversityRRRichard J. RomanState Street (United States)

Discussion

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Implication

Provides mechanistic insight into ACE inhibition in rodent kidney; leaves open translation to human cardiorenal therapy.

Structured PICO

P
Population
Munich-Wistar rats with elevated plasma renin activity, renal denervation, and controlled renal perfusion pressure
I
Intervention
Captopril (2 mg/kg iv) with subsequent infusions of ANG II (20 ng.kg-1.min-1 iv), saralasin, or a kinin antagonist
C
Comparator
Baseline/control state
O
Outcome
Renal hemodynamic response including urine flow, sodium excretion, renal blood flow (RBF), glomerular filtration rate (GFR), and cortical and papillary red blood cell (RBC) flowsurrogate

In a rat model, captopril alters renal hemodynamics through both angiotensin II-mediated cortical vasoconstriction relief and kinin-mediated papillary vasodilation.

Cite This Study

Mattson et al. (1991) studied this question.

synapsesocial.com/papers/6a7dbab3f3499a80f78c9562https://doi.org/10.1152/ajprenal.1991.260.5.f670
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between inhibition of renal angiotensin II production and hemodynamic effect of captopril in anesthetized rabbit1992 · 12 citations
  2. 2Captopril-induced Changes in Prostaglandin Production1980 · 336 citations
  3. 3ANGIOTENSINS II AND III PREVENT CAPTOPRIL‐INDUCED RENIN RELEASE IN THE RAT1988 · 6 citations
  4. 4Regional Renal Haemodynamics of Angiotensin II Infusion under Prostaglandin, Kinin or Converting Enzyme Inhibition in the Wistar Rat2000 · 5 citations
  5. 5Captopril Enhances Vascular and Adrenal Responsiveness to Angiotensin II in Essential Hypertension1984 · 10 citations