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February 1, 1988Clinical and Experimental Pharmacology and PhysiologyOpen Access

Angiotensins Ii and Iii Prevent Captopril‐induced Renin Release in the Rat

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Why the study?

Do exogenous angiotensins II and III prevent captopril-induced renin release in anaesthetized rats?

Population

Anaesthetized Sprague-Dawley rats

Comparison

Exogenous angiotensins II and III pre-infusion… vs Saline-injected controls and captopril alone

Design

Preclinical

Authors

GMGerhard MoldenhauerMedigene (Germany)MSMartin SmithUniversity of the WitwatersrandRNR. Di NicolantonioNovartis (Spain)

Discussion

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Implication

Leaves open clinical translation of ACE inhibitor effects; extends experimental evidence for angiotensin feedback on renin in rats.

Structured PICO

Do exogenous angiotensins II and III prevent captopril-induced renin release in anaesthetized rats?

P
Population
Anaesthetized Sprague-Dawley rats
I
Intervention
Exogenous angiotensins II and III (50 pmol/min i.v.) pre-infusion followed by captopril injection (5 mg/kg, i.v.)
C
Comparator
Saline-injected controls and captopril alone
O
Outcome
Plasma renin concentrationsurrogate

Captopril induces renin release by inhibiting angiotensin II feedback control of renin secretion, which can be reversed by exogenous angiotensin II or III.

Cite This Study

Moldenhauer et al. (1988) studied this question.

synapsesocial.com/papers/6a709b035d37378ac1ddba78https://doi.org/10.1111/j.1440-1681.1988.tb01052.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Des-1-Asp-angiotensin II. Possible intrarenal role in homeostasis in the dog.1975 · 45 citations
  2. 2Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs1965 · 349 citations
  3. 3Determination of Plasma Renin Concentration by Angiotensin I Immunoassay: Diagnostic Import of Precise Measurement of Subnormal Renin in Hyperaldosteronism1971 · 111 citations
  4. 4Long-Term Treatment of Hypertension in Man by an Orally Active Angiotensin-Converting Enzyme Inhibitor1978 · 20 citations
  5. 5Effects of Renal Arterial Infusion of Sodium and Potassium on Renin Secretion in the Dog1972 · 62 citations