January 1, 1987Clinical and Experimental Hypertension Part A Theory and Practice

Effect of Captopril on Angiotensin II Release from Vascular Tissues in Rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does captopril inhibit the conversion of vascular ANG I into ANG II in isolated rat hindlegs?

Population

Isolated rat hindlegs (from nephrectomized and control rats)

Comparison

Pretreatment with captopril for 3 days or… vs Control group (no captopril)

Design

Preclinical

Authors

MNMitsuaki NakamaruKawamura Hospital TITadashi InagamiHeart Failure / Cardiomyopathy TOToshio OgiharaNihon University

Discussion

Member takes

Implication

May support local vascular ACE inhibition by captopril in rats; leaves open translation to human hypertension therapy.

Structured PICO

Does captopril inhibit the conversion of vascular ANG I into ANG II in isolated rat hindlegs?

Population

Isolated rat hindlegs (from nephrectomized and control rats)

Intervention

Pretreatment with captopril (50 mg/kg/day) for 3 days or addition of captopril (2 X 10(-6) M) to the perfusate

Comparator

Control group (no captopril)

Outcome

Release of angiotensin I (ANG I) and angiotensin II (ANG II)surrogate

Captopril inhibits the local conversion of vascular angiotensin I into angiotensin II in rat vascular tissues.

Cite This Study

Nakamaru et al. (1987) studied this question.

synapsesocial.com/papers/6a227e80ffccceb004b72f0d https://doi.org/10.3109/10641968709164216

View Full Paper

Ask AI

Bookmark

Effect of Captopril on Angiotensin II Release from Vascular Tissues in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Captopril on Angiotensin II Release from Vascular Tissues in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider