Key result
Systemic infusion of angiotensin II increased papillary blood perfusion in a dose-dependent manner, a response mediated via AT1 receptors and dependent on the presence of nitric oxide.
Why the study?
Does systemic infusion of angiotensin II affect papillary blood perfusion in rats, and what are the underlying mechanisms?
Does systemic infusion of angiotensin II affect papillary blood perfusion in rats, and what are the underlying mechanisms?
Angiotensin II increases papillary blood perfusion in rats via AT1 receptors and NO-dependent mechanisms, independent of bradykinin B2 receptors.
No takes yet. Share an insight, caveat, or question.
Should not yet alter clinical practice; extends AT1-NO mechanisms of papillary perfusion in rodents.
Walker et al. (1999) studied this question. Angiotensin II (AII) vs. Losartan, HOE-140, and NOLA was evaluated on Papillary blood perfusion (PBP) and mean arterial blood pressure (MAP). Systemic infusion of angiotensin II increased papillary blood perfusion in a dose-dependent manner, a response mediated via AT1 receptors and dependent on the presence of nitric oxide.
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