Why the study?
Does AT1 receptor blockade with losartan modulate the renal and systemic hemodynamic effects of acute or chronic nitric oxide inhibition in rats?
Does AT1 receptor blockade with losartan modulate the renal and systemic hemodynamic effects of acute or chronic nitric oxide inhibition in rats?
The arterial hypertension and renal vasoconstriction seen in chronic NO deficiency are partially mediated by angiotensin II via AT1 receptors, unlike the effects of acute NO inhibition.
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AT1 blockade may mitigate chronic NO-deficient hypertension in rats; leaves open translation to human endothelial dysfunction or NO-related disease.
Ortíz et al. (1998) studied this question.
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