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September 1, 1998Hypertension

Regulation of Angiotensin II Receptor Expression by Nitric Oxide in Rat Adrenal Gland

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Why the study?

Does inhibition of NO synthesis by L-NAME affect angiotensin II receptor gene expression and aldosterone secretion in rats?

Population

Wistar King A rats

Comparison

L-NAME alone or with bunazosin for 1 week vs Normal water

Design

Preclinical

Follow-up

1 week

Authors

MUMakoto UsuiPanasonic (Japan)TIToshihiro IchikiKyushu UniversityMKMakoto KatohKanazawa University

Discussion

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Overview

Supports BP-independent aldosterone effects in this rat model; hypothesis-generating for human fibrosis with no clinical implications yet.

Structured PICO

Does inhibition of NO synthesis by L-NAME affect angiotensin II receptor gene expression and aldosterone secretion in rats?

P
Population
Wistar King A rats
I
Intervention
L-NAME (1 mg/mL in drinking water) alone or with bunazosin (0.1 mg/mL in drinking water) for 1 week
C
Comparator
Normal water
O
Outcome
Expression of Ang II receptors in the adrenal gland and aldosterone secretion (systolic blood pressure, plasma aldosterone concentration, AT1-R mRNA and number)surrogate

Inhibition of NO synthesis increases adrenal AT1 receptor expression and aldosterone secretion independently of blood pressure, potentially contributing to myocardial fibrosis.

Cite This Study

Usui et al. (1998) studied this question.

synapsesocial.com/papers/6a6ff3fbce524a4339c3c495https://doi.org/10.1161/01.hyp.32.3.527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.1992 · 260 citations
  2. 2Regulation of Angiotensin II Type 2 Receptor Gene by the Protein Kinase C–Calcium Pathway1996 · 49 citations
  3. 3Cardiac weight in hypertension induced by nitric oxide synthase blockade.1993 · 183 citations
  4. 4Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin1 receptors.1995 · 322 citations
  5. 5Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.1992 · 794 citations