Population
Normal rats
Comparison
Chronic administration of Nomega-nitro-L-arginine… vs Control (no L-NAME)
Design
Preclinical
Follow-up
4 weeks
Authors
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Transient Ang II receptor upregulation in NO-deficient rats may link to early cardiac inflammation; human relevance remains untested.
Chronic inhibition of NO synthesis in rats transiently upregulates cardiac Ang II receptors, which may contribute to early cardiovascular inflammatory changes and later remodeling.
Katoh et al. (1998) studied this question.
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