Population
Anesthetized rats
Comparison
Losartan administered during low- and high-dose… vs Control animals and varying doses of NLA without…
Design
Preclinical
Follow-up
short-term
Authors
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AT1 blockade may attenuate modest NOS-induced renal vasoconstriction in animals; leaves open its role during strong inhibition and any human translation.
AT1-receptor blockade with losartan attenuates modest but not strong renal vasoconstriction induced by nitric oxide inhibition, suggesting the functional role of endogenous ANG II in vascular tone is diminished during strong NOS inhibition.
Turkstra et al. (1998) studied this question.
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