Population
Rat isolated kidneys perfused in the presence of indomethacin at constant flow in a single-pass circuit
Comparison
AT1 receptor antagonist and AT2 receptor… vs Absence of NO blockade or absence of AT-receptor…
Design
Preclinical
Authors
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Remains preclinical in rat renal vessels; leaves open translation to human NO-deficient vascular disease.
In rat renal vasculature, Angiotensin II-induced vasoconstriction becomes sensitive to both AT1 and AT2 receptor antagonists when nitric oxide synthesis is inhibited.
Müller et al. (1997) studied this question.
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