December 28, 2005AJP Renal Physiology

Angiotensin II AT2receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway

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Why the study?

Does activation of AT2 receptors inhibit Na+-K+-ATPase activity via a NO/cGMP-dependent pathway in proximal tubules of Sprague-Dawley rats?

Population

Proximal tubules isolated from Sprague-Dawley rats

Comparison

AT2 receptor agonist CGP-42112 (10-10 M) and ANG… vs Baseline/control or presence of antagonists and…

Design

Preclinical

Authors

AHAmer C. HakamUniversity of Houston THTahir HussainUniversity of Houston

Discussion

Member takes

Implication

AT2-mediated natriuresis may involve tubular NO/cGMP signaling in rats; leaves open human relevance and therapeutic translation.

Structured PICO

Does activation of AT2 receptors inhibit Na+-K+-ATPase activity via a NO/cGMP-dependent pathway in proximal tubules of Sprague-Dawley rats?

Population

Proximal tubules isolated from Sprague-Dawley rats

Intervention

AT2 receptor agonist CGP-42112 (10(-10)-10(-7) M) and ANG II (100 nM)

Comparator

Baseline/control or presence of antagonists (PD-123319, losartan) and inhibitors (ODQ, L-NAME)

Outcome

Na+-K+-ATPase (NKA) activitysurrogate

Activation of the AT2 receptor inhibits Na+-K+-ATPase activity in the proximal tubules via the NO/cGMP pathway, providing a mechanism for AT2 receptor-mediated natriuresis and diuresis.

Cite This Study

Hakam et al. (2005) studied this question.

synapsesocial.com/papers/6a7c28a6050daa66a5df7ed7 https://doi.org/10.1152/ajprenal.00218.2005

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Angiotensin II AT2receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II AT2receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider