Key result
AT2 receptor activation induces natriuresis and opposes AT1 receptor effects, highlighting the therapeutic potential of AT2 receptor agonists like Compound 21 in hypertension.
AT2 receptor activation represents a potential therapeutic target for inducing natriuresis and managing fluid-retaining states and hypertension.
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Should not yet change hypertension practice; leaves open AT2 agonist efficacy in prospective trials.
Carey et al. (2013) conducted a review in Hypertension and fluid-retaining states. AT2 receptor activation (e.g., Compound 21) was evaluated. AT2 receptor activation induces natriuresis and opposes AT1 receptor effects, highlighting the therapeutic potential of AT2 receptor agonists like Compound 21 in hypertension.
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