Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2001American Journal of HypertensionOpen Access

Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implications

View Full Paper
Ask AI
Bookmark
Share

Population

Adult rat models and general discussion on the pathophysiology of hypertension

Design

Review

Authors

RCRobert M. CareyUniversity of Virginia

Discussion

Loading...

Member takes

Overview

AT2 agonism merits investigation in hypertension; leaves open whether agonists will prove clinically effective.

Structured PICO

P
Population
Adult rat models and general discussion on the pathophysiology of hypertension
I
Intervention
Angiotensin AT2 receptor agonists / AT1 receptor blockade
O
Outcome
Blood pressure regulation (vasodilation and hypotension)

The AT2 receptor mediates vasodilation and hypotension, presenting a potential novel therapeutic target for the treatment of hypertension.

Cite This Study

Robert M. Carey (2001) studied this question.

synapsesocial.com/papers/6a74ab718d2049c8dd033369https://doi.org/10.1016/s0895-7061(01)02076-3
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.1996 · 313 citations
  2. 2Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein1994 · 151 citations
  3. 3Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT 2 ) angiotensin receptor1999 · 329 citations
  4. 4Protective Role of the Angiotensin AT 2 Receptor in a Renal Wrap Hypertension Model1999 · 246 citations
  5. 5AT2Receptor Stimulation Enhances Antihypertensive Effect of AT1Receptor Antagonist in Hypertensive Rats1999 · 147 citations