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January 1, 1990Circulation ResearchOpen Access

Bradykinin contribution to renal blood flow effect of angiotensin converting enzyme inhibitor in the conscious sodium-restricted dog.

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Population

6 conscious sodium-deprived dogs instrumented for monitoring of blood pressure and renal blood flow

Comparison

Enalaprilat administered alone or during… vs Enalaprilat alone vs. enalaprilat with antagonists

Design

Preclinical

Authors

BZBen G. ZimmermanOregon Health & Science UniversityPRP. C. RaichUniversity of MinnesotaRVRaymond J. VavrekUniversity of Iowa

Discussion

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Implication

Supports bradykinin contribution to ACEI renal vasodilation in sodium-depleted animals; hypothesis-generating, requires human confirmation.

Structured PICO

P
Population
6 conscious sodium-deprived dogs instrumented for monitoring of blood pressure and renal blood flow
I
Intervention
Enalaprilat administered alone or during infusion of saralasin (intravenous or intrarenal) or a specific bradykinin antagonist (B5630)
C
Comparator
Enalaprilat alone vs. enalaprilat with antagonists
O
Outcome
Changes in blood pressure (BP) and renal blood flow (RBF)surrogate

Bradykinin potentiation contributes significantly to the renal vasodilatory effects of ACE inhibitors in sodium-depleted states.

Cite This Study

Zimmerman et al. (1990) studied this question.

synapsesocial.com/papers/6a7daf4d603f5e16dd339f08https://doi.org/10.1161/01.res.66.1.234
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disappearance of bradykinin in the renal circulation of dogs. Effects of kininase inhibition.1975 · 150 citations
  2. 2Micropuncture evidence of rapid hydrolysis of bradykinin by rat proximal tubule1976 · 81 citations
  3. 3A BRADYKININ‐POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARACA1965 · 509 citations
  4. 4ROLE OF THE KALLIKREIN‐KININ SYSTEM IN THE RENAL EFFECTS OF ANGIOTENSIN‐CONVERTING ENZYME INHIBITION IN ANAESTHETIZED DOGS1981 · 26 citations
  5. 5The Effect of the Converting Enzyme Inhibitor SQ 20.881 on Kinins, Renin‐Angiotensin‐Aldosterone and Catecholamines in Relation to Blood Pressure in Hypertensive Patients1978 · 48 citations