Population
Conscious male Sprague-Dawley rats, chronically instrumented, 2 weeks after streptozotocin or citrate vehicle
Comparison
Enalapril with or without pretreatment with… vs Normal rats vs diabetic rats, and responses…
Design
Preclinical
Authors
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Bradykinin may mediate sympathoexcitation with acute ACE inhibition in diabetic models; leaves open human relevance and chronic effects.
Enhanced bradykinin signaling mediates the baroreflex-independent sympathoexcitatory effect of acute ACE inhibition with enalapril in diabetic rats.
Augustyniak et al. (2007) studied this question.
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