Why the study?
Does central Ang-(1-7) antagonism with A-779 reduce baroreflex sensitivity in enalapril-treated renovascular hypertensive rats?
Population
Two-kidney, one clip renovascular hypertensive rats with blood pressure > 145 mm Hg and sham-operated rats
Comparison
Intracerebroventricular infusion of selective… vs I.C.V. infusion of saline (8 microL/h)
Design
Preclinical
Follow-up
6 days of enalapril treatment followed by 1 hour of I.C.V…
Authors
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Supports central Ang-(1-7) mediation of enalapril baroreflex effects in rats; leaves open translation to human renovascular hypertension.
Does central Ang-(1-7) antagonism with A-779 reduce baroreflex sensitivity in enalapril-treated renovascular hypertensive rats?
Central endogenous Ang-(1-7) is involved in the improvement of baroreflex sensitivity observed after peripheral chronic ACE inhibition in renovascular hypertensive rats.
Britto et al. (1997) studied this question.
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