September 1, 1997Hypertension

Potentiation of the Hypotensive Effect of Bradykinin by Short-term Infusion of Angiotensin-(1-7) in Normotensive and Hypertensive Rats

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Why the study?

Does angiotensin-(1-7) potentiate the hypotensive effect of bradykinin in normotensive and hypertensive rats?

Structured PICO

Does angiotensin-(1-7) potentiate the hypotensive effect of bradykinin in normotensive and hypertensive rats?

Population

Conscious male Wistar rats (normotensive), renal hypertensive rats (RHR produced by aorta coarctation), and spontaneously hypertensive rats (SHR)

Intervention

Angiotensin-(1-7) intravenous infusion (0.3 pmol/min or 5 pmol/min) alone or combined with A-779 (5 pmol/min) or enalaprilat (10 mg/kg I.V.)

Comparator

Saline infusion (0.9% NaCl, 5 microL/min)

Outcome

Hypotensive effect of bradykinin (change in mean arterial pressure) after intravenous bolus injectionssurrogate

Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in both normotensive and hypertensive rats, suggesting it acts as an endogenous modulator of kinin vascular actions.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May guide kinin modulation studies in hypertensive rat models; leaves open human therapeutic translation.

Cite This Study

Lima et al. (1997) studied this question.

synapsesocial.com/papers/6a70836dac440176ef292de1 https://doi.org/10.1161/01.hyp.30.3.542

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Potentiation of the Hypotensive Effect of Bradykinin by Short-term Infusion of Angiotensin-(1-7) in Normotensive and Hypertensive Rats

Structured PICO

Discussion

Implication

Cite This Study

Topics

Potentiation of the Hypotensive Effect of Bradykinin by Short-term Infusion of Angiotensin-(1-7) in Normotensive and Hypertensive Rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider