January 1, 1997Hypertension

Bovine Aortic Endothelial Cells Contain an Angiotensin-(1–7) Receptor

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Population

Cultured bovine aortic endothelial cells

Design

Preclinical

Authors

ETE. Ann TallantAtrium Health Wake Forest Baptist XLXiaowei LuStanford University RWRandi B. WeissWake Forest University

Discussion

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Implication

Hypothesis-generating for a distinct endothelial Ang-(1-7) receptor; leaves open its functional role and human hypertension relevance.

Structured PICO

Population

Cultured bovine aortic endothelial cells

Intervention

Binding assays with [125I]angiotensin-(1-7) and various competitors (sarcosine1-isoleucine8-angiotensin II, D-alanine7-angiotensin-(1-7), losartan, PD 123319, angiotensin II)

Outcome

Presence and characteristics of [125I]angiotensin-(1-7) binding sites (affinity, density, and competition profiles)surrogate

Bovine aortic endothelial cells possess a unique non-AT1, non-AT2 receptor that preferentially binds angiotensin-(1-7), providing a potential mechanism for its counter-regulatory effects in the renin-angiotensin system.

Cite This Study

Tallant et al. (1997) studied this question.

synapsesocial.com/papers/6a70836dac440176ef292de2 https://doi.org/10.1161/01.hyp.29.1.388

View Full Paper

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Bovine Aortic Endothelial Cells Contain an Angiotensin-(1–7) Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bovine Aortic Endothelial Cells Contain an Angiotensin-(1–7) Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider