Key result
Cultured bovine aortic endothelial cells express renin and secrete Angiotensin II, which stimulates smooth muscle cell proliferation via the AT1 receptor.
Population
Cultured bovine aortic endothelial cells and aorta smooth muscle cells (ASMC)
Comparison
Angiotensin II and conditioned medium from… vs Control (untreated cells)
Design
Preclinical
Follow-up
1 to 2 days (in vitro)
Authors
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May implicate local endothelial Ang II in vascular remodeling; hypothesis-generating and requires human confirmation.
Vascular endothelial cells locally synthesize renin and generate Ang II, which can stimulate smooth muscle cell proliferation via the AT1 receptor.
Xiao et al. (2000) studied this question. Angiotensin II and conditioned medium vs. Controls was evaluated on Smooth muscle cell proliferation. Cultured bovine aortic endothelial cells express renin and secrete Angiotensin II, which stimulates smooth muscle cell proliferation via the AT1 receptor.
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