Why the study?
Does microinjection of Ang-(1-7) into the nucleus tractus solitarii modulate baroreflex sensitivity in normotensive and spontaneously hypertensive rats?
Population
Urethane anesthetized male Wistar rats and spontaneously hypertensive rats (SHR)
Comparison
Bilateral microinjection of Ang- or its… vs Saline (vehicle) microinjection
Design
Preclinical
Authors
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No immediate clinical implications; extends animal evidence for Ang-(1-7) baroreflex modulation but leaves open human translation.
Does microinjection of Ang-(1-7) into the nucleus tractus solitarii modulate baroreflex sensitivity in normotensive and spontaneously hypertensive rats?
Ang-(1-7) exerts a tonic modulatory effect on baroreflex control of heart rate at the nTS, with reduced sensitivity observed in spontaneously hypertensive rats.
Chaves et al. (2000) studied this question.
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