Effect of blockade of endogenous angiotensin II on baroreflex function in conscious diabetic rats

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Population

Conscious, chronically instrumented rats 2 weeks after citrate vehicle or 55 mg/kg iv streptozotocin

Comparison

Losartan (5 mg/kg iv) or enalapril (2.5 mg/kg iv) vs Normal rats and baseline measurements before…

Design

Preclinical

Authors

Discussion

ANG II blockade fails to restore baroreflex function in early diabetic rats; leaves open relevance to human autonomic neuropathy.

Population

Conscious, chronically instrumented rats 2 weeks after citrate vehicle (normal) or 55 mg/kg iv streptozotocin (diabetic)

Intervention

Losartan (5 mg/kg iv) or enalapril (2.5 mg/kg iv)

Comparator

Normal rats (citrate vehicle) and baseline measurements before drug administration

Outcome

Baroreflex control of renal nerve sympathetic activity (RSNA) and heart rate (HR)surrogate

Blockade of endogenous angiotensin II does not improve baroreflex dysfunction in a rat model of early diabetes.

Maliszewska-Ścisło et al. (2003) studied this question.

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