Why the study?
Does chronic NO synthase inhibition affect arterial pressure and renal function in rats at the onset of Type I diabetes?
Population
Rats with modified streptozotocin-induced Type I diabetes at the earliest stages of diabetes
Comparison
Chronic nitric oxide (NO) synthase inhibition vs Diabetic rats without NO synthase inhibition
Design
Preclinical
Authors
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May support NO's protective role against early diabetic hypertension in rats; leaves open human translation.
Does chronic NO synthase inhibition affect arterial pressure and renal function in rats at the onset of Type I diabetes?
Nitric oxide may counteract the pressor response at the onset of diabetic hyperglycemia by facilitating renal vasodilation and suppressing the renin-angiotensin system.
Michael W. Brands (2001) studied this question.
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