Why the study?
Does central infusion of ANG II or losartan alter cardiac baroreflex function in conscious normotensive rabbits?
Population
Conscious normotensive rabbits
Comparison
Fourth ventricular infusion of ANG II or… vs Fourth ventricular infusion of Ringer solution…
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
Central ANG II modulation of baroreflex gain is unproven in humans; leaves open translation from rabbit models to clinical practice.
Does central infusion of ANG II or losartan alter cardiac baroreflex function in conscious normotensive rabbits?
Endogenous central ANG II provides long-term modulation of cardiac baroreflexes independent of blood pressure levels.
Gaudet et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: