Why the study?
Does intracerebroventricular losartan alter basal renal sympathetic nerve activity and cardiac baroreflex regulation in conscious rats on varying sodium diets?
Population
Conscious rats consuming a low, normal, or high sodium diet, instrumented for simultaneous measurement of…
Comparison
Intracerebroventricular losartan vs Vehicle treatment
Design
Preclinical
Authors
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Central angiotensin II tonically modulates sympathetic activity and baroreflex in rats; hypothesis-generating for human salt-sensitive hypertension therapies.
Does intracerebroventricular losartan alter basal renal sympathetic nerve activity and cardiac baroreflex regulation in conscious rats on varying sodium diets?
Endogenous angiotensin II activity tonically influences basal renal sympathetic nerve activity and its cardiac baroreflex regulation, dependent on dietary sodium intake.
DiBona et al. (1998) studied this question.
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