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February 1, 1998AJP Heart and Circulatory PhysiologyOpen Access

Angiotensin receptor antagonist improves cardiac reflex control of renal sodium handling in heart failure

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Why the study?

Does losartan improve cardiac baroreflex regulation of renal sympathetic nerve activity and renal sodium handling in rats with congestive heart failure?

Population

Rats with congestive heart failure

Comparison

Losartan vs Vehicle

Design

Preclinical

Authors

GDGerald F. DiBonaGeneral CardiologySJSusan Y. JonesUniversity of IowaLSLinda L. SawinUniversity of Iowa

Discussion

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Implication

Hypothesis-generating in experimental heart failure; leaves open clinical translation of baroreflex and natriuretic effects.

Structured PICO

Does losartan improve cardiac baroreflex regulation of renal sympathetic nerve activity and renal sodium handling in rats with congestive heart failure?

P
Population
Rats with congestive heart failure
I
Intervention
Losartan (type 1 angiotensin II receptor antagonist)
C
Comparator
Vehicle
O
Outcome
Cardiac baroreflex regulation of renal sympathetic nerve activity and renal sodium handlingsurrogate

In a rat model of heart failure, losartan improves cardiac baroreflex regulation of renal sympathetic nerve activity and enhances the ability to excrete acute and chronic sodium loads.

Cite This Study

DiBona et al. (1998) studied this question.

synapsesocial.com/papers/6a82d61dabc87fc4bf1e20d1https://doi.org/10.1152/ajpheart.1998.274.2.h636

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANG II receptor blockade and arterial baroreflex regulation of renal nerve activity in cardiac failure1995 · 154 citations
  2. 2Effect of endogenous angiotensin II on renal nerve activity and its arterial baroreflex regulation1996 · 62 citations
  3. 3Reflex regulation of renal nerve activity in cardiac failure1994 · 129 citations
  4. 4Neural control of renal function in edema-forming states1988 · 133 citations
  5. 5Pressure-independent baroreflex resetting produced by chronic infusion of angiotensin II in rabbits1993 · 63 citations