Why the study?
Does acute AT1 receptor blockade with losartan improve depressed baroreflex sensitivity in chronic renal hypertensive rats?
Population
Normotensive rats (N=6) and chronically hypertensive rats (1K1C model, 2 months, N=7)
Comparison
Losartan 10 mg/kg intravenous vs Baseline values and normotensive control rats
Design
Preclinical
Follow-up
15 minutes
Authors
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Acute losartan lowers BP without restoring baroreflex sensitivity in renal hypertensive rats; leaves open Ang II independence of baroreflex impairment.
Does acute AT1 receptor blockade with losartan improve depressed baroreflex sensitivity in chronic renal hypertensive rats?
Acute AT1 receptor blockade lowers blood pressure but does not reverse baroreflex hyposensitivity in chronic renal hypertensive rats, suggesting the impairment is independent of elevated angiotensin II levels.
Farah et al. (2000) studied this question.
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