Why the study?
Does losartan or captopril improve baroreflex control of heart rate in coarcted hypertensive rats?
Population
Coarcted hypertensive rats and sham-coarcted rats
Comparison
Losartan or captopril vs Vehicle
Design
Preclinical
Follow-up
5 days after coarctation
Authors
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Losartan but not captopril may normalize baroreflex control in this model; leaves open differential central AT1 effects on autonomic regulation in hypertension.
Does losartan or captopril improve baroreflex control of heart rate in coarcted hypertensive rats?
In a rat model of coarctation hypertension, central AT1 receptor blockade with losartan, but not ACE inhibition with captopril, normalizes baroreflex control of heart rate.
Santos et al. (1995) studied this question.
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